Activation of P2Y1 and P2Y12 receptors, through secreted ADP that is stimulated by
agonists such as thrombin, thromboxane and collagen, is a major mechanism of platelet …

The P2Y12 receptor, a Gi protein-coupled receptor, plays a central role in platelet activation.
In this study, we did a mutational analysis of residues possibly involved in the ligand …

2-Chloro-N 6-methyl-(N)-methanocarba-2′-deoxyadenosine-3′, 5′-bisphosphate
(MRS2279) was developed previously as a selective high-affinity, non-nucleotide P2Y1 …

Eight human G protein-coupled P2Y receptors (P2Y1, P2Y2, P2Y4, P2Y6, P2Y11, P2Y12,
P2Y13, and P2Y14) that respond to extracellular nucleotides have been molecularly …

Since the first cloning of P2Y receptor sequences in 1993 it has become apparent that this
family of G-protein-coupled receptors is omnipresent. At least 25 individual sequences …

Abstract P2Y receptors are G-protein-coupled receptors (GPCRs) for extracellular
nucleotides. There are eight mammalian P2Y receptor subtypes (P2Y1, P2Y2, P2Y4, P2Y6 …

The P2Y12 receptor plays a crucial role in platelet aggregation. In the present study, we
analyzed the properties of non-nucleotide antagonists at the recombinant human P2Y12 …

In the present study, we investigated the desensitization and trafficking of the P2Y1 and
P2Y12 receptors after agonist-induced stimulation of platelets or astrocytoma cells …

P2Y receptors are G-protein-coupled receptors activated by extracellular nucleotides. The
P2Y6 receptor is selectively activated by UDP, and its transcript has been detected in …

We recently cloned and expressed a novel P2Y receptor (tp2y receptor) from a turkey cDNA
library. Expression of this receptor in 1321N1 human astrocytoma cells confers nucleotide …