The P2Y1 receptor is present in the heart, in skeletal and various smooth muscles, and in
platelets, where its activation is linked to aggregation. Adenosine 3 ', 5 '-and 2 ', 5 ' …

Pharmacological properties of the human P2Y1 receptor transfected in Jurkat cells and of
the endogenous receptor in rat brain capillary endothelial cells were analyzed under …

The human P2Y1 receptor (P2Y1-R) was purified after high-level expression from a
recombinant baculovirus in Sf9 insect cells. Quantification by protein staining and with a …

An intronless open reading frame encoding a protein (361aa in length) was isolated from a
rat genomic library probed with a DNA fragment from rat heart. This protein showed 83 …

G protein‐linked P2Y nucleotide receptors are known commonly to stimulate the
phosphoinositide signalling pathway. However, we have previously demonstrated that the …

P2Y receptors are a class of G protein-coupled receptors activated primarily by ATP, UTP,
and UDP. Five mammalian P2Y receptors have been cloned so far including P2Y1, P2Y2 …

Eight G protein–coupled P2Y receptor (P2YR) subtypes are important physiologic
mediators. The human P2YRs are fully activated by ATP (P2Y2 and P2Y11), ADP (P2Y1 …

The biological actions of extracellular nucleotides are exerted via two families of P2
receptors, P2X and P2Y. The metabotropic P2Y receptors comprise at least 7 distinct …

Abstract Professor Geoffrey Burnstock proposed the concept of purinergic signaling via P1
and P2 receptors. P2Y receptors are G-protein-coupled receptors (GPCRs) for extracellular …

The P2Y11 receptor is hypothesized to link to both Gs and Gq, although this proposition is
based on expression and separate assays of Gs and Gqfunction in different cell types [J Biol …