1 The rat homologue of the P2Y1 receptor has been heterologously expressed in 1321N1
human astrocytoma cells and in C6 rat glioma cells. 2 As has been shown previously for the …

The aim of the present study was to characterize the pharmacological profile of the P2Y 12
receptor for several adenine triphosphate nucleotides in view of their possible roles as …

We conducted a mutational analysis of residues potentially involved in the adenine
nucleotide binding pocket of the human P2Y1receptor. Mutated receptors were expressed in …

Purine and pyrimidine nucleotides have been identified as potent extracellular signalling
molecules, acting at two classes of cell surface receptors, ionotropic P2X and metabotropic …

Although the effects of nucleotides in the cardiovascular system have been known for almost
70 years, it is only in the past few years that some of the P2 receptors at which they act have …

Abstract P2Y receptors are G-protein-coupled receptors (GPCRs) for extracellular
nucleotides. There are eight mammalian P2Y receptor subtypes (P2Y 1, P2Y 2, P2Y 4, P2Y …

Publisher Summary Since the cloning of the first two members of the P2Y receptor family—
the P2Y 1 and P2Y 2 receptors—a number of related sequences have been isolated from …

Adenosine 5′-triphosphate (ATP) and/or related nucleotides act at both ionotrophic (P2X)
and metabotropic (P2Y) receptors. P2X receptors subunits (P2X1—P2X7) form ligand-gated …

Nucleotides are ubiquitous intercellular messengers whose actions are mediated by specific
receptors. Since the first clonings in 1993, it is known that nucleotide receptors belong to two …

ATP, UTP, and their corresponding disphosphates function as intercellular signaling
molecules when released to, or generated within, extracellular compartments. Genes …