Abstract P2Y receptors are G-protein-coupled receptors (GPCRs) for extracellular
nucleotides. There are eight mammalian P2Y receptor subtypes divided into two subgroups …

P2 receptors are present in virtually all tissues and cell types in the human body, and they
mediate the physiological and pharmacological actions of extracellular purine and …

The nucleotide selectivities of the human P2Y4 (hP2Y4) and rat P2Y4 (rP2Y4) receptor
stably expressed in 1321N1 human astrocytoma cells were determined by measuring …

The P2Y family of receptors are G protein‐coupled receptors for ATP, ADP, UTP and UDP.
Recently several members of this family have been cloned, including the P2Y4, which is …

In addition to its key role in cellular metabolism where it acts as a ubiquitous enzyme
cofactor and as the key source of the cellular energy unique to phosphate bond formation …

Extracellular nucleotides have been implicated in a number of physiological functions.
Nucleotides act on cell-surface receptors known as P2 receptors, of which several subtypes …

1. Four different phospholipase C (PLC)-activating P2Y receptors have been cloned and
stably expressed in 1321N1 human astrocytoma cells. These include the human …

The cDNA encoding a novel P 2 receptor was isolated from rat aortic smooth muscle cell
library and functionally characterized. The cloned P 2 receptor exhibits structural features …

There are eight subtypes of P2Y receptors (P2YRs) that are activated, and in some cases
inhibited, by a range of extracellular nucleotides. These nucleotides are ubiquitous, but their …

P2Y receptors inhibiting adenylyl cyclase have been found in blood platelets, glioma cells,
and endothelial cells. In platelets and glioma cells, these receptors were identified as …