Internationally renowned basic and clinical scientists provide an account of our best current
understanding of the genetics of cancer. These authoritative contributors describe in detail …

THE most enduring hypothesis concerning the origin of cancer is that some genetic
alteration—induced by the environment, by predisposition, or by both factors acting in …

For many years, discoveries about the genetic determinants of cancer appeared to be
having only minor effects on efforts to control the disease in the clinic. Following advances …

In this paper I will consider an aspect of carcinogenesis that needs further in-depth study
because it could be a major cause of human cancers. I am referring to the Damoclean …

Publisher Summary Cancer results from the accumulation of a series of genetic errors into a
single somatic cell genome. A wide range of potential mutagens increases the likelihood of …

Peyton Rous opened his Nobel lecture of 1966 with the following passage:" Tumors destroy
man in a unique and appalling way, as flesh of his own flesh which has somehow been …

Atumor isolated from a patient is a large aggregation of cancer cells, all of them descended
from a sin gle" founder" cell. The single ancestor was once a normal cell, with a normal …

The past two decades have been golden years for the genetics of cancer. It has become
clear through the work of countless laboratory groups that both inherited and sporadic …

In the dozen years since the genetics of human cancer was first reviewed in these pages, we
have achieved an understanding of the processes governing cell growth and differentiation …

Carcinogenesis may result from the action of any one or a combination of chemical,
physical, biologic, and/or genetic insults to cells. The process of carcinogenesis may be …