T cell tolerance to self antigens is at least partly a reflection of clonal deletion of immature T
cells in the thymus. Although it is well accepted that intrathymic tolerance is primarily a …

In experimental systems, T-cell tolerance to foreign antigens can reflect deletion, anergy or
suppression. The relative contribution of these 3 mechanisms to self-tolerance, however …

The immune system is constructed to tolerate self antigens but give vigorous responses to
foreign antigens. How this state of self/nonself discrimination is maintained is controversial …

Self tolerance among T cells is believed to be maintained by two principal mechanisms:
clonal deletion for self antigens expressed in the thymus and T cell anergy or T cell …

The most efficient way to ensure self-tolerance in the T-cell repertoire is by intrathymic
deletion of self-reactive clones. Antigens not present intrathymically may, however, influence …

Immunologie self-tolerance is achieved largely by clonal deletion of self-reactive
CD4+/CD8+ cells in the thymus (reviewed on pp 1-33). However, it has been proposed that …

There is now convincing evidence for the imposition of self-tolerance by means of the clonal
deletion of self-reactive T cells operating within the thymus. Experiments with monoclonal …

Despite the acceptance of principles such as clonal deletion in the thymus and peripheral
clonal anergy, several new issues have arisen in the study of T-cell tolerance. For example …

During the past 3 years, considerable progress has been generated in understanding the
mechanisms by which developing T cells acquire tolerance for self-antigens. Clonal deletion …

Several recent observations, from different laboratories and experimental systems have led
to the same con-.•.... c dusion: to ensure transplantation tolerance, it is-, ul-ficient to'tolerize'a …