Placental LPL gene expression is increased in severe intrauterine growth-restricted pregnancies

S Tabano, G Alvino, P Antonazzo, FR Grati… - Pediatric …, 2006 - nature.com
Intrauterine growth restriction (IUGR) is associated with reduced placental supply of
nutrients to the fetus. Lipoprotein lipase (LPL) mediates the hydrolysis of triglycerides from …

Placental lipoprotein lipase activity is positively associated with newborn adiposity

MJR Heerwagen, DL Gumina, TL Hernandez… - Placenta, 2018 - Elsevier
Introduction Recent data suggest that in addition to glucose, fetal growth is related to
maternal triglycerides (TG). To reach the fetus, TG must be hydrolyzed to free fatty acids …

Effect of maternal triglycerides and free fatty acids on placental LPL in cultured primary trophoblast cells and in a case of maternal LPL deficiency

AL Magnusson-Olsson, S Lager… - American Journal …, 2007 - journals.physiology.org
Maternal hypertriglyceridemia is a normal condition in late gestation and is an adaptation to
ensure an adequate nutrient supply to the fetus. Placental lipoprotein lipase (LPL) is …

Intrauterine growth restriction is associated with alterations in placental lipoprotein receptors and maternal lipoprotein composition

C Wadsack, S Tabano, A Maier… - American Journal …, 2007 - journals.physiology.org
Among other factors, fetal growth requires maternal supply of cholesterol. Cellular
cholesterol uptake is mainly mediated by the LDL receptor (LDL-R) and the scavenger …

Placental lipoprotein lipase DNA methylation levels are associated with gestational diabetes mellitus and maternal and cord blood lipid profiles

AA Houde, J St-Pierre, MF Hivert… - … origins of health and …, 2014 - cambridge.org
Placental lipoprotein lipase (LPL) is crucial for placental lipid transfer. Impaired LPL gene
expression and activity were reported in pregnancies complicated by gestational diabetes …

Placental lipase expression in pregnancies complicated by preeclampsia: a case–control study

HL Barrett, MH Kubala, K Scholz Romero… - Reproductive Biology …, 2015 - Springer
Background Preeclampsia (PE) is associated with maternal and neonatal morbidity and
mortality. In PE, the physiological hyperlipidaemia of pregnancy is exaggerated. The …

Gestational and hormonal regulation of human placental lipoprotein lipase

AL Magnusson-Olsson, B Hamark, A Ericsson… - Journal of lipid …, 2006 - ASBMB
The fetal demand for FFA increases as gestation proceeds, and LPL represents one
potential mechanism for increasing placental lipid transport. We examined LPL activity and …

Dysregulation of placental endothelial lipase and lipoprotein lipase in intrauterine growth-restricted pregnancies

M Gauster, U Hiden, A Blaschitz, S Frank… - The Journal of …, 2007 - academic.oup.com
Context: Fetal supply of maternally derived fatty acids requires lipase-mediated hydrolysis of
lipoprotein-borne triglycerides and phospholipids at the placental surface. Objective: The …

Maternal undernutrition leads to elevated hepatic triglycerides in male rat offspring due to increased expression of lipoprotein lipase

WF Zhu, JF Zhu, L Liang… - Molecular Medicine …, 2016 - spandidos-publications.com
Small for gestational age (SGA) at birth increases the risk of developing metabolic
syndrome, which encompasses various symptoms including hypertriglyceridemia. The aim …

Lipoprotein lipase and lipid profiles in plasma and placenta from normal pregnancies compared with patients with intrahepatic cholestasis of pregnancy

ZM Hao, YF Ye, YK Zhang, SF Yang, XL Ye - European Journal of …, 2016 - Elsevier
Objective To analyse lipoprotein lipase (LPL) expression and lipid levels in placenta and
plasma of patients with intrahepatic cholestasis of pregnancy (ICP) and normal pregnancies …