Depression represents the number one cause of disability worldwide and is often fatal.
Inflammatory processes have been implicated in the pathophysiology of depression. It is …

Major depressive disorder (MDD) is a chronic, recurrent, and severe psychiatric disorder
with high mortality and medical comorbidities. Stress‐related pathways have been directly …

The monoamine hypothesis of depression has dominated our understanding of both the
pathophysiology of depression and the action of pharmacological treatments for the last …

Depression is a complex disorder that takes an enormous toll on individual health. As
affected individuals display a wide variation in their clinical symptoms, the precise neural …

Recent studies combining pharmacological, behavioral, electrophysiological and molecular
approaches indicate that depression results from maladaptive neuroplastic processes …

Background Most of our knowledge of the biological basis of major depressive disorder
(MDD) is derived from studies of chronic stress models in rodents. While these models …

The underlying causes of most mood and anxiety disorders remain unknown. There is a
strong heritable component to psychiatric illnesses that, when coupled with environmental …

Depression is a common cause of mortality and morbidity, but the biological bases of the
deficits in emotional and cognitive processing remain incompletely understood. Current …

Major depression (MD) is a severe, lifethreatening, and highly prevalent psychiatric disorder,
predicted to soon become one of the major causes of death worldwide. Despite extensive …

It has become clear that the inflammatory immune system is altered during the course of
clinical depression. In particular, studies on human patients have found depression to be …