A plethora of evidence suggests that protein misfolding and aggregation are underlying
mechanisms of various neurodegenerative diseases, such as prion diseases and …

Specific protein misfolding and aggregation are mechanisms underlying various
neurodegenerative diseases such as prion disease and Alzheimer's disease (AD). The …

Mammalian prions cause lethal neurodegenerative diseases such as Creutzfeldt–Jakob
disease (CJD) and consist of multi-chain assemblies of misfolded cellular prion protein …

Alzheimer's disease (AD) is the most common neurodegenerative disease in humans and
will pose a considerable challenge to healthcare systems in the coming years. Aggregation …

The pathological features of Alzheimer's disease (AD) include senile plaques induced by
amyloid-β (Aβ) protein deposits, neurofibrillary tangles formed by aggregates of …

Neurodegeneration is becoming one of the leading causes of death worldwide as the
population expands and grows older. There is a growing desire to understand the …

Alzheimer's disease (AD) is a devastating neurodegenerative disease with progressive loss
of memory and cognitive function, pathologically hallmarked by aggregates of the amyloid …

Alzheimer disease (AD) is the most prevalent cause of dementia. Amyloid-β (Aβ) oligomers
are potent synaptotoxins thought to mediate AD-related phenotypes. Cellular prion protein …

Amyloid-β (Aβ) and tau are the pathogenic hallmarks in Alzheimer's disease (AD). Aβ
oligomers are considered the actual toxic entities, and the toxicity relies on the presence of …

Prefibrillar oligomers of the β-amyloid peptide (Aβ) are recognized as potential mediators of
Alzheimer's disease (AD) pathophysiology. Deficits in synaptic function, neurotoxicity, and …