Most chronic inflammatory illnesses include fibrosis as a pathogenic characteristic.
Extracellular matrix (ECM) components build up in excess to cause fibrosis or scarring. The …

Fibrosis, or tissue scarring, develops as a pathological deviation from the physiological
wound healing response and can occur in various organs such as the heart, lung, liver …

Fibrosis denotes excessive scarring, which exceeds the normal wound healing response to
injury in many tissues. Although the extracellular matrix deposition appears unstructured …

Fibrosis is the excessive deposition of extracellular matrix components, which results in
disruption of tissue architecture and loss of organ function. Fibrosis leads to high morbidity …

Fibrosis, a non-physiological wound healing in multiple organs, is associated with end-stage
pathological symptoms of a wide variety of vascular injury and inflammation related …

Human fibrotic diseases constitute a major health problem worldwide owing to the large
number of affected individuals, the incomplete knowledge of the fibrotic process …

Fibrosis is a pathological scarring process that leads to destruction of organ architecture and
impairment of organ function. Chronic loss of organ function in most organs, including bone …

Acute inflammation is a recognised part of normal wound healing. However, when
inflammation fails to resolve and a chronic inflammatory response is established this …

Fibrosis — A Common Pathway to Organ Injury and Failure | New England Journal of Medicine
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Tissue fibrosis, a serious and even deadly complication of chronic inflammation and
environmental exposures, is regulated by a host of factors including interactions with the …