Tumor necrosis factor (TNF), a potent inflammatory cytokine, and mitochondrial DNA
(mtDNA), a product of inflammation-induced tissue damage, increase with age …

Highlights•Neutrophils are increasingly recognized as multi-faceted immune cells.•In aged
hosts, neutrophils show inaccurate chemotaxis and reduced NET formation.•Neutrophils …

Over the past millennia, life expectancy has drastically increased. While a mere 25 years
during Bronze and Iron ages, life expectancy in many European countries and in Japan is …

The average age of the human population is rising, leading to an increasing burden of age‐
related diseases, including increased susceptibility to infection. However, immune function …

Human neutrophils are activated by a wide array of compounds through their receptors. This
elicits their classical functions, such as chemotaxis, phagocytosis, and the production of …

Impaired immune function has been implicated in the declining health and higher incidence
of cancer in the elderly. However, age-related changes to immunity are not completely …

Elderly humans are more susceptible to bacterial infections because of declining immune
status. We have investigated the effect of aging on neutrophil bactericidal responses …

Under steady-state conditions, aged neutrophils are removed from the circulation in bone
marrow, liver, and spleen, thereby maintaining myeloid cell homeostasis. The fate of these …

The aim of our study was to analyze polymorphonuclear neutrophil (PMN) functions in
elderly individuals compared with those in healthy young participants, directly in whole …

Neutrophils are first-responders, providing early protection against invading pathogens.
Recent findings have revealed a temporal dimension to neutrophil function, associated with …