Acute myeloid leukemia: biologic, prognostic, and therapeutic insights

S Khaled, M Al Malki, G Marcucci - Oncology, 2016 - go.gale.com
Acute myeloid leukemia (AML) is a biologically complex and molecularly and clinically
heterogeneous disease, and its incidence is increasing as the population ages …

Molecular alterations in acute myeloid leukemia and their clinical and therapeutical implications

MS Infante, MÁ Piris, JÁ Hernández-Rivas - Medicina Clínica (English …, 2018 - Elsevier
Acute myeloid leukaemia is the most common form of acute leukaemia, and its incidence
increases with age. The disease derives from a transformed multipotent malignant …

Targeted AML therapy: new biologic paradigms and therapeutic opportunities

CL Willman - Leukemia, 2001 - nature.com
With rapid scientific advances in human genomics, proteomics, experimental therapeutics,
and bioinformatics, the ability to optimize therapy for acute myelogenous leukemia (AML) …

Descriptive and functional genomics in acute myeloid leukemia (AML): paving the road for a cure

H Pasquer, M Tostain, N Kaci, B Roux, L Benajiba - Cancers, 2021 - mdpi.com
Simple Summary Acute myeloid leukemia (AML) accounts for 7.6% of hematopoietic
malignancies with a long-term survival of less than 20%. Better understanding its …

Current and emerging molecular and epigenetic disease entities in acute myeloid leukemia and a critical assessment of their therapeutic modalities

X Zhao, H Liu, LN Wang, L Yang, X Liu - Seminars in Cancer Biology, 2022 - Elsevier
Acute myeloid leukemia (AML) is the most frequently diagnosed acute leukemia, and its
incidence increases with age. Although the etiology of AML remains unknown, exposure to …

Genomic applications in the clinic: use in treatment paradigm of acute myeloid leukemia

RF Schlenk, H Döhner - Hematology 2013, the American …, 2013 - ashpublications.org
In recent years, research in genomics has resulted in the rapid uncovering of the molecular
pathogenesis of acute myeloid leukemia (AML). The identification of the genetic …

DNA microarrays in the diagnosis and management of acute lymphoblastic leukemia

AA Ferrando, A Thomas Look - International journal of hematology, 2004 - Springer
The significant progress in the treatment of acute lymphoblastic leukemia (ALL) experienced
over the last 3 decades has been driven mainly by the empirical combination of antileukemic …

Acute myeloid leukemia

FR Appelbaum, JM Rowe, J Radich… - ASH Education …, 2001 - ashpublications.org
Through the hard work of a large number of investigators, the biology of acute myeloid
leukemia (AML) is becoming increasingly well understood, and as a consequence, new …

The rocky road to personalized medicine in acute myeloid leukaemia

B Brinda, I Khan, B Parkin… - Journal of cellular and …, 2018 - Wiley Online Library
Acute myeloid leukaemia (AML) is a malignant disorder of the myeloid blood lineage
characterized by impaired differentiation and increased proliferation of hematopoietic …

Introduction to the review series on advances in acute myeloid leukemia (AML)

B Löwenberg, JM Rowe - Blood, The Journal of the American …, 2016 - ashpublications.org
Acute myeloid leukemia (AML) is the most common form of acute leukemia, with an
incidence that increases with advanced age. Although it is usually of unknown etiology, it …