The evolving molecular genetic landscape in acute myeloid leukaemia

MA Sanders, PJM Valk - Current opinion in hematology, 2013 - journals.lww.com
The list of acquired mutations with clinical value in AML is growing. Clinical implementation
of this multitude of markers will require integrated approaches and selection of markers to …

[HTML][HTML] Recent advances in the understanding and treatment of acute myeloid leukemia

J Watts, S Nimer - F1000Research, 2018 - ncbi.nlm.nih.gov
Acute myeloid leukemia (AML) is a clinically and genetically heterogeneous disease that
has a poor prognosis. Recent advances in genomics and molecular biology have led to a …

Progress in acute myeloid leukemia

TM Kadia, F Ravandi, S O'Brien, J Cortes… - … Myeloma and Leukemia, 2015 - Elsevier
Significant progress has been made in the treatment of acute myeloid leukemia (AML).
Steady gains in clinical research and a renaissance of genomics in leukemia have led to …

Clinical importance of cytogenetics in acute myeloid leukaemia

K Mrózek, K Heinonen, CD Bloomfield - Best Practice & Research Clinical …, 2001 - Elsevier
Acquired chromosome aberrations are present in the marrow of most patients with acute
myeloid leukaemia (AML) at diagnosis. Cytogenetically, AML is a very heterogeneous …

Impact of cytogenetics on clinical outcome in AML

D Grimwade - Acute myelogenous leukemia, 2007 - Springer
Over the last three decades it has become clear that a significant proportion of cases of
acute myeloid leukemia (AML) are characterized by at least one of a variety of recurrent …

New perspectives in treating acute myeloid leukemia: driving towards a patient-tailored strategy

F Andreozzi, F Massaro, S Wittnebel… - International journal of …, 2022 - mdpi.com
For decades, intensive chemotherapy (IC) has been considered the best therapeutic option
for treating acute myeloid leukemia (AML), with no curative option available for patients who …

An expert overview of emerging therapies for acute myeloid leukemia: novel small molecules targeting apoptosis, p53, transcriptional regulation and metabolism

K Saxena, M Konopleva - Expert Opinion on Investigational Drugs, 2020 - Taylor & Francis
Introduction Acute myeloid leukemia (AML) is an aggressive malignancy of clonal myeloid
precursor cells. Curative therapy has classically involved the use of intensive induction …

Advances in understanding the biology and genetics of acute myelocytic leukemia

SB McKenzie - American Society for Clinical Laboratory Science, 2005 - clsjournal.ascls.org
Acute myelocytic leukemia (AML) is a malignant neoplasm of hematopoietic cells
characterized by an abnormal proliferation of myeloid precursor cells, decreased rate of self …

Current treatment of acute myeloid leukemia

GJ Roboz - Current opinion in oncology, 2012 - journals.lww.com
Current treatment of acute myeloid leukemia : Current Opinion in Oncology Current treatment of
acute myeloid leukemia : Current Opinion in Oncology Log in or Register Subscribe to …

A comprehensive review of genetic alterations and molecular targeted therapies for the implementation of personalized medicine in acute myeloid leukemia

A Kirtonia, G Pandya, G Sethi, AK Pandey… - Journal of molecular …, 2020 - Springer
Acute myeloid leukemia (AML) is an extremely heterogeneous disease defined by the clonal
growth of myeloblasts/promyelocytes not only in the bone marrow but also in peripheral …