The phagocytic function of macrophages plays a pivotal role in eliminating apoptotic cells
and invading pathogens. Evidence implicating plasminogen (Plg), the zymogen of plasmin …

It is widely held that the plasminogen (Plg) system plays a role in inflammation through
plasmin-mediated directional cell migration. However, substantial evidence for its …

The elimination of apoptotic cells, called efferocytosis, is fundamentally important for tissue
homeostasis and prevents the onset of inflammation and autoimmunity. Serum proteins are …

Inflammation resolution is an active process that functions to restore tissue homeostasis.
Clearance of apoptotic leukocytes by efferocytosis at inflammatory sites plays an important …

Plasminogen (Plg) facilitates inflammatory cell recruitment, a function that depends upon its
binding to Plg receptors (Plg-Rs). However, the Plg-Rs that are critical for cell migration are …

Essentials• Plg‐R KT is a novel integral membrane plasminogen receptor.• The functions of
Plg‐R KT in vivo are not known.• Plg‐R KT is a key player in macrophage recruitment in the …

The plasminogen (Plg)/plasmin (Pla) system is associated with a variety of biological
activities beyond the classical dissolution of fibrin clots, including cell migration, tissue …

Efficient migration of macrophages to sites of inflammation requires cell surface–bound
plasmin (ogen). Here, we investigated the mechanisms underlying the deficits of plasmin …

Localization of plasmin on macrophages and activation of pro–MMP-9 play key roles in
macrophage recruitment in the inflammatory response. These functions are promoted by …

Plasminogen knock-out (PG−/−) mice provide an unique opportunity for the study of
alternative mediators of fibrinolysis. Polymorphonuclear leucocytes (PMNs) contain non …