Metabolite profiling has been established as a multiparallel strategy for relative
quantification of a mixture of compounds or compound classes using chromatography and …

Highlights•Metabolomics enables rapid measurements at 10–100 times higher throughput
than proteomics.•The achievable throughput opens entirely new scientific and medical …

Highlights•Chromatography-based mass spectrometry (MS) allows profiling 100 samples
per day.•Thousands of samples per day can be efficiently analyzed by omitting …

Gas chromatography coupled to mass spectrometry (GC-MS) is one of the most frequently
used tools for profiling primary metabolites. Instruments are mature enough to run large …

Obtaining comprehensive, untargeted metabolic profiles for complex solid samples, eg,
animal tissues, requires sample preparation and access to information-rich analytical …

A critical question facing the field of metabolomics is whether data obtained from different
centers can be effectively compared and combined. An important aspect of this is the …

Gas chromatography coupled to mass spectrometry (GC/MS) is a core analytical method for
metabolomics and has been used as a platform in non-targeted analysis, especially for …

High-resolution mass spectrometry (MS) has advanced the study of metabolism in living
systems by allowing many metabolites to be measured in a single experiment. Although …

Properly implemented, metabolic and lipidomic profiling can provide a deeper
understanding of mammalian, plant and bacterial biology. These omics-tools have …

The metabolic investigation of the human population is becoming increasingly important in
the study of health and disease. The phenotypic variation can be investigated through the …