Modern analytical technologies afford comprehensive and quantitative investigation of a
multitude of different metabolites. Typical metabolomic experiments can therefore produce …

Highlights•Metabolomics provides a functional read-out of the physiological status of an
organism.•A precise (dynamic) description of the clinical phenotype is missing for complex …

Analysis of metabolomic profiling data from gas chromatography− mass spectrometry
(GC/MS) measurements usually relies upon reference libraries of metabolite mass spectra to …

Background: Metabolomics is increasingly recognized as an invaluable tool in the
biological, medical and environmental sciences yet lags behind the methodological maturity …

Mass spectrometry‐based metabolomics has become increasingly popular in molecular
medicine. High‐definition mass spectrometry (MS), coupled with pattern recognition …

Untargeted metabolomics refers to the high-throughput analysis of the metabolic state of a
biological system (eg, tissue, biological fluid, cell culture) based on the concentration profile …

This review presents an overview of the dynamically developing field of mass spectrometry‐
based metabolomics. Metabolomics aims at the comprehensive and quantitative analysis of …

Metabolomics is the comprehensive assessment of endogenous metabolites and attempts to
systematically identify and quantify metabolites from a biological sample. Small-molecule …

Introduction We previously developed a tandem mass spectrometry-based label-free
targeted metabolomics analysis framework coupled to two distinct chromatographic …

Metabonomics and metabolomics represent one of the three major platforms in systems
biology. To perform metabolomics it is necessary to generate comprehensive “global” …