Metabolomics has emerged in the past decade as a highly attractive and impactful
technique for phenotype-level profiling in diverse biological applications. Most recently, the …

The metabolome is the terminal downstream product of the genome and consists of the total
complement of all the low‐molecular‐weight molecules (metabolites) in a cell, tissue, or …

Highlights•We review high-throughput mass spectrometry-based methods for metabolomic
analysis.•High-throughput approaches usually improve throughput at the expense of …

Background Metabolite profiling, the simultaneous quantification of multiple metabolites in
an experiment, is becoming increasingly popular, particularly with the rise of systems-level …

Mass spectrometry (MS) is an established technology in drug metabolite analysis and is now
expanding into endogenous metabolite research. Its utility derives from its wide dynamic …

Recently, metabolomics analyses have become increasingly common in the general
scientific community as it is applied in several researches relating to diseases diagnosis …

Advances in liquid chromatography-mass spectrometry (LC-MS) instruments and analytical
strategies have brought about great progress in targeted metabolomics analysis. This …

Targeted metabolomics has significant advantages for quantification but suffers from
reduced metabolite coverage. In this study, we developed a large-scale targeted …

The gap of the post-genomic era is increasingly being filled by the metabolomics approach,
comprising a technology for analyzing small molecule endogenous metabolites (≤ 1500 …

Background Metabolomics experiments involve generating and comparing small molecule
(metabolite) profiles from complex mixture samples to identify those metabolites that are …