A strategy for identifying differences in large series of metabolomic samples analyzed by GC/MS
P Jonsson, J Gullberg, A Nordström… - Analytical …, 2004 - ACS Publications
In metabolomics, the purpose is to identify and quantify all the metabolites in a biological
system. Combined gas chromatography and mass spectrometry (GC/MS) is one of the most …
system. Combined gas chromatography and mass spectrometry (GC/MS) is one of the most …
Cross-platform comparison of methods for quantitative metabolomics of primary metabolism
Quantitative metabolomics is under intense development, and no commonly accepted
standard analytical technique has emerged, yet. The employed analytical methods were …
standard analytical technique has emerged, yet. The employed analytical methods were …
Data acquisition workflows in liquid chromatography coupled to high resolution mass spectrometry-based metabolomics: Where do we stand?
F Fenaille, PB Saint-Hilaire, K Rousseau… - … of Chromatography a, 2017 - Elsevier
Typical mass spectrometry (MS) based untargeted metabolomics protocols are tedious as
well as time-and sample-consuming. In particular, they often rely on “full-scan-only” …
well as time-and sample-consuming. In particular, they often rely on “full-scan-only” …
Current trends and challenges in sample preparation for global metabolomics using liquid chromatography–mass spectrometry
D Vuckovic - Analytical and bioanalytical chemistry, 2012 - Springer
The choice of sample-preparation method is extremely important in metabolomic studies
because it affects both the observed metabolite content and biological interpretation of the …
because it affects both the observed metabolite content and biological interpretation of the …
MyCompoundID: using an evidence-based metabolome library for metabolite identification
Identification of unknown metabolites is a major challenge in metabolomics. Without the
identities of the metabolites, the metabolome data generated from a biological sample …
identities of the metabolites, the metabolome data generated from a biological sample …
[HTML][HTML] Statistical workflow for feature selection in human metabolomics data
High-throughput metabolomics investigations, when conducted in large human cohorts,
represent a potentially powerful tool for elucidating the biochemical diversity underlying …
represent a potentially powerful tool for elucidating the biochemical diversity underlying …
Globally optimized targeted mass spectrometry: reliable metabolomics analysis with broad coverage
Targeted detection is one of the most important methods in mass spectrometry (MS)-based
metabolomics; however, its major limitation is the reduced metabolome coverage that results …
metabolomics; however, its major limitation is the reduced metabolome coverage that results …
High-throughput and multiplexed LC/MS/MRM method for targeted metabolomics
R Wei, G Li, AB Seymour - Analytical chemistry, 2010 - ACS Publications
Target-based metabolomics, focused on a subset of metabolites representative of key
pathways, is a valuable tool for assessing metabolic changes resulting from genetic …
pathways, is a valuable tool for assessing metabolic changes resulting from genetic …
[HTML][HTML] “Notame”: workflow for non-targeted LC–MS metabolic profiling
Metabolomics analysis generates vast arrays of data, necessitating comprehensive
workflows involving expertise in analytics, biochemistry and bioinformatics in order to …
workflows involving expertise in analytics, biochemistry and bioinformatics in order to …
Representing the metabolome with high fidelity: range and response as quality control factors in LC-MS-based global profiling
Liquid chromatography–mass spectrometry (LC-MS) is a powerful and widely used
technique for measuring the abundance of chemical species in living systems. Its sensitivity …
technique for measuring the abundance of chemical species in living systems. Its sensitivity …