An overview of metabolomics data analysis: current tools and future perspectives

S Lamichhane, P Sen, AM Dickens… - Comprehensive …, 2018 - Elsevier
Metabolomics is a study of small molecules in the body and the associated metabolic
pathways and is considered to provide a close link between organism's genotype and …

Standardizing gc–ms metabolomics

H Kanani, PK Chrysanthopoulos, MI Klapa - Journal of Chromatography B, 2008 - Elsevier
Metabolomics being the most recently introduced “omic” analytical platform is currently at its
development phase. For the metabolomics to be broadly deployed to biological and clinical …

Metabolomics platform with capillary electrophoresis coupled with high-resolution mass spectrometry for plasma analysis

K Sasaki, H Sagawa, M Suzuki, H Yamamoto… - Analytical …, 2018 - ACS Publications
Metabolome analysis using capillary electrophoresis (CE) coupled with high-resolution
mass spectrometry (HRMS) has the potential to improve coverage of metabolite detection …

Procedure for tissue sample preparation and metabolite extraction for high-throughput targeted metabolomics

W Römisch-Margl, C Prehn, R Bogumil, C Röhring… - Metabolomics, 2012 - Springer
Reproducible quantification of metabolites in tissue samples is of high importance for
characterization of animal models and identification of metabolic changes that occur in …

Mass spectrometry—based metabolomics, analysis of metabolite-protein interactions, and imaging

DY Lee, BP Bowen, TR Northen - Biotechniques, 2010 - Future Science
Our understanding of biology has been greatly improved through recent developments in
mass spectrometry, which is providing detailed information on protein and metabolite …

Metabolite measurement: pitfalls to avoid and practices to follow

W Lu, X Su, MS Klein, IA Lewis, O Fiehn… - Annual review of …, 2017 - annualreviews.org
Metabolites are the small biological molecules involved in energy conversion and
biosynthesis. Studying metabolism is inherently challenging due to metabolites' reactivity …

XCMS: processing mass spectrometry data for metabolite profiling using nonlinear peak alignment, matching, and identification

CA Smith, EJ Want, G O'Maille, R Abagyan… - Analytical …, 2006 - ACS Publications
Metabolite profiling in biomarker discovery, enzyme substrate assignment, drug
activity/specificity determination, and basic metabolic research requires new data …

High resolution mass spectrometry based techniques at the crossroads of metabolic pathways

C Junot, F Fenaille, B Colsch… - Mass spectrometry …, 2014 - Wiley Online Library
The metabolome is the set of small molecular mass compounds found in biological media,
and metabolomics, which refers to as the analysis of metabolome in a given biological …

Automated label-free quantification of metabolites from liquid chromatography–mass spectrometry data

E Kenar, H Franken, S Forcisi, K Wörmann… - Molecular & Cellular …, 2014 - ASBMB
Liquid chromatography coupled to mass spectrometry (LC-MS) has become a standard
technology in metabolomics. In particular, label-free quantification based on LC-MS is easily …

A practical approach to detect unique metabolic patterns for personalized medicine

JM Johnson, T Yu, FH Strobel, DP Jones - Analyst, 2010 - pubs.rsc.org
Information-rich technologies have advanced personalized medicine, yet obstacles limit
measurement of large numbers of chemicals in human samples. Current laboratory tests …