[HTML][HTML] Comparison of epidermal growth factor receptor mutations between primary and corresponding metastatic tumors in tyrosine kinase inhibitor-naive non-small …

CH Gow, YL Chang, YC Hsu, MF Tsai, CT Wu, CJ Yu… - Annals of …, 2009 - Elsevier
Background Mutations of the epidermal growth factor receptor (EGFR) gene in non-small-
cell lung cancer (NSCLC) patients predict the patients who will respond to EGFR tyrosine …

EGFR Mutation Heterogeneity and the Mixed Response to EGFR Tyrosine Kinase Inhibitors of Lung Adenocarcinomas

ZY Chen, WZ Zhong, XC Zhang, J Su, XN Yang… - The …, 2012 - academic.oup.com
Background. Non-small cell lung cancer patients with epidermal growth factor receptor
(EGFR) mutations have mixed responses to tyrosine kinase inhibitors (TKIs). Intertumor …

Mutation in the tyrosine kinase domain of epidermal growth factor receptor is a predictive and prognostic factor for gefitinib treatment in patients with non–small cell …

TY Chou, CH Chiu, LH Li, CY Hsiao, CY Tzen… - Clinical cancer …, 2005 - AACR
Purpose: Mutations in epidermal growth factor receptor (EGFR) can be used to predict the
tumor response of patients receiving gefitinib for non–small cell lung cancer (NSCLC). We …

Effect of epidermal growth factor receptor tyrosine kinase domain mutations on the outcome of patients with non–small cell lung cancer treated with epidermal growth …

PA Jänne, BE Johnson - Clinical cancer research, 2006 - AACR
Somatic mutations in the epidermal growth factor receptor (EGFR) have been identified in
patients with advanced non–small cell lung cancer who achieve dramatic clinical and …

Relative Abundance of EGFR Mutations Predicts Benefit From Gefitinib Treatment for Advanced Non–Small-Cell Lung Cancer

Q Zhou, XC Zhang, ZH Chen, XL Yin… - Journal of clinical …, 2011 - ascopubs.org
Purpose Our aim was to determine whether abundance of epidermal growth factor receptor
(EGFR) mutations in tumors predicts benefit from treatment with EGFR–tyrosine kinase …

[HTML][HTML] An alternative method for screening EGFR mutation using RFLP in non-small cell lung cancer patients

I Kawada, K Soejima, H Watanabe, I Nakachi… - Journal of Thoracic …, 2008 - Elsevier
Introduction Epidermal growth factor receptor (EGFR) mutations are strong determinants of
tumor response to EGFR tyrosine kinase inhibitors in non-small cell lung cancers (NSCLCs) …

[HTML][HTML] De novo resistance to epidermal growth factor receptor-tyrosine kinase inhibitors in EGFR mutation-positive patients with non-small cell lung cancer

M Takeda, I Okamoto, Y Fujita, T Arao, H Ito… - Journal of Thoracic …, 2010 - Elsevier
Background Somatic mutations in the epidermal growth factor receptor (EGFR) gene are a
predictor of response to treatment with EGFR tyrosine kinase inhibitors (TKIs) in patients with …

[HTML][HTML] Discordance of molecular biomarkers associated with epidermal growth factor receptor pathway between primary tumors and lymph node metastasis in non …

S Park, AJ Holmes-Tisch, YM Shim, J Kim… - Journal of Thoracic …, 2009 - Elsevier
Introduction: For the identification of the patients who most likely benefit from epidermal
growth factor receptor (EGFR) tyrosine kinase inhibitors in non-small cell lung cancer …

High concordance of EGFR mutation status between histologic and corresponding cytologic specimens of lung adenocarcinomas

PL Sun, Y Jin, H Kim, CT Lee, S Jheon… - Cancer …, 2013 - Wiley Online Library
BACKGROUND Activating mutations in the epidermal growth factor receptor (EGFR) in non–
small cell lung carcinoma (NSCLC) are associated significantly with responsiveness to …

Mutation-Specific Antibodies for the Detection of EGFR Mutations in Non–Small-Cell Lung Cancer

J Yu, S Kane, J Wu, E Benedettini, D Li, C Reeves… - Clinical Cancer …, 2009 - AACR
Purpose: Activating mutations within the tyrosine kinase domain of epidermal growth factor
receptor (EGFR) are found in approximately 10% to 20% of non–small-cell lung cancer …