T HE effect induced by a drug is the resultant of the interaction between the molecules of the
drug and the molecules of which the biological object is composed. The higher the …

For an active drug molecule to be therapeutically effective it must reach the site of its
intended pharmacologic activity within the body at a sufficient rate and in sufficient amounts …

Our understanding of the molecular organization of even the simplest mammalian cell
membrane--that of the red blood cell--is still incomplete, yet we are reasonably sure of …

The concept of the pharmacological receptor was introduced by Langley 28 and by Ehrlich.
11 Langley's formulation was based on experiments in which he applied nicotine to small …

We ought firstly to consider the boundaries of the field which we seek to classify. If we do not
use the term “receptor” rigorously and consistently, the range of structures involved becomes …

Publisher Summary When studying the mechanisms by which drug molecules exert their
influence on physiological functions, different degrees of specificity can be seen at the …

The importance of the dose-response curve, or concentration-effect relation, in
pharmacology is perhaps most strikingly reflected in the fact that in the year in which the …

PERHAPS the best way to introduce the subject matter of the following discussion is by
quoting Furchgott (1955), who remarked in an authoritative review of the mechanism of …

It is a usual assumption that the selective transport of proteins across cell plasma
membranes is mediated by receptor molecules located in the membranes. The function of …