Pathophysiology of paroxysmal and persistent atrial fibrillation: rotors, foci and fibrosis

DH Lau, D Linz, U Schotten, R Mahajan… - Heart, Lung and …, 2017 - Elsevier
Recent advances in our understanding of the mechanisms underlying atrial fibrillation (AF)
have further underscored the complex pathophysiological basis of the arrhythmia. It has …

Atrial fibrillation from the pathologist's perspective

D Corradi - Cardiovascular pathology, 2014 - Elsevier
Atrial fibrillation (AF), the most common sustained cardiac arrhythmia encountered in clinical
practice, is associated with increased morbidity and mortality. Electrophysiologically, it is …

Atrial fibrosis and substrate based characterization in atrial fibrillation: time to move forwards

JX Quah, D Dharmaprani, K Tiver… - Journal of …, 2021 - Wiley Online Library
Atrial fibrillation (AF) is the most commonly encountered cardiac arrhythmia in clinical
practice. However, current therapeutic interventions for atrial fibrillation have limited clinical …

[HTML][HTML] The atrium in atrial fibrillation–a clinical review on how to manage atrial fibrotic substrates

PS Cunha, S Laranjo, J Heijman… - Frontiers in …, 2022 - frontiersin.org
Atrial fibrillation (AF) is the most common sustained arrhythmia in the population and is
associated with a significant clinical and economic burden. Rigorous assessment of the …

The value of basic research insights into atrial fibrillation mechanisms as a guide to therapeutic innovation: a critical analysis

J Heijman, V Algalarrondo, N Voigt… - Cardiovascular …, 2016 - academic.oup.com
Atrial fibrillation (AF) is an extremely common clinical problem associated with increased
morbidity and mortality. Current antiarrhythmic options include pharmacological, ablation …

Fibrosis and atrial fibrillation: computerized and optical mapping: a view into the human atria at submillimeter resolution

BJ Hansen, J Zhao, VV Fedorov - JACC: Clinical Electrophysiology, 2017 - jacc.org
Recent studies strongly suggest that the majority of atrial fibrillation (AF) patients with
diagnosed or subclinical cardiac diseases have established or even pre-existing fibrotic …

[HTML][HTML] Atrial fibrillation: mechanisms, therapeutics, and future directions

J Pellman, F Sheikh - Comprehensive Physiology, 2015 - ncbi.nlm.nih.gov
Atrial fibrillation (AF) is the most prevalent cardiac arrhythmia, affecting 1% to 2% of the
general population. It is characterized by rapid and disorganized atrial activation leading to …

Human atrial fibrillation substrate: towards a specific fibrotic atrial cardiomyopathy

H Kottkamp - European heart journal, 2013 - academic.oup.com
The atrial structure/substrate of patients with atrial fibrillation (AF) and clinically similar
characteristics can present very differently, and also the 'phenotype'(ie paroxysmal …

Intermittent drivers anchoring to structural heterogeneities as a major pathophysiological mechanism of human persistent atrial fibrillation

M Haissaguerre, AJ Shah, H Cochet… - The Journal of …, 2016 - Wiley Online Library
The mechanisms responsible for perpetuation of human persistent atrial fibrillation (AF) are
controversial and probably vary between individuals. A wide spectrum of mechanisms have …

Electrophysiological and molecular mechanisms of paroxysmal atrial fibrillation

S Nattel, D Dobrev - Nature Reviews Cardiology, 2016 - nature.com
Atrial fibrillation (AF) is an extremely prevalent arrhythmia that presents a wide range of
therapeutic challenges. AF usually begins in a self-terminating paroxysmal form (pAF). With …