To better understand the pathogenesis of nephrolithiasis, we developed a new animal
model that closely mimics human calcium oxalate stone disease. Rats were treated with a …

Purpose: The availability of various transgenic and knockout mice provides an excellent
opportunity to better understand the pathophysiology of calcium oxalate stone disease …

Calcium oxalate stone disease is the most common human urinary stone disease in the
Western Hemisphere. To understand different aspects of the disease, calcium oxalate …

Crystallization of salts in the urine is a process common to many mammals including
humans. The crystals are either harmlessly excreted as crystalluria particles or are retained …

In human nephrolithiasis, most stones are containing calcium and are located within urinary
cavities; they may contain monohydrate calcium oxalate, dihydrate calcium oxalate and/or …

Calcific kidney stones in both humans and mildly hyperoxaluric rats are located on renal
papillary surfaces and consist of an organic matrix and crystals of calcium oxalate and/or …

Environment and diet have a major role in calcium nephrolithiasis by affecting urine
saturation, but this is not enough to cause lithogenesis; the crystals must adhere to the …

Calcium oxalate (CaOx) urolithiasis in rats is induced by producing hyperoxaluria.
Depending on the degree and length of hyperoxaluria, CaOx crystals may either form in the …

Dietary oxalate is plant-derived and may be a component of vegetables, nuts, fruits, and
grains. In normal individuals, approximately half of urinary oxalate is derived from the diet …

Renal tubular cell damage, resulting in membranuria, was induced by the administration of
subcutaneous gentamicin to male Sprague-Dawley rats. One group of rats received …