Multidrug resistance (MDR) in cancer cells can lead to chemotherapeutic failure. The lack of
effective therapies has created a growing need for developing new and effective …

Cancer stands as a prominent global cause of death. One of the key reasons why clinical
tumor chemotherapy fails is multidrug resistance (MDR). In recent decades, accumulated …

One of the greatest challenges in cancer treatment is the intrinsic development of multidrug
resistance (MDR). Several hypotheses with experimental evidence, such as altered drug …

Multidrug resistance (MDR) continues to be a major challenge to effective chemotherapeutic
interventions against cancer. Various types of cancers have been observed to exhibit this …

Multidrug resistance (MDR) in human cancer is one of greatest challenges in cancer
therapy. Natural products, especially the alkaloids, exert reversed effects on MDR with low …

Cancer is a prominent cause of death globally. Currently, many drugs that are in clinical
practice are having a high prevalence of side effect and multidrug resistance. Risk of tumors …

Cancer is one of the leading causes of global mortality and morbidity. It is caused by
dysregulation of key cellular processes. Treatment of cancer focuses on re-regulation of …

Multidrug resistance (MDR) is a major obstacle to successful cancer chemotherapy. One of
the main underlying mechanisms of this resistance is the over-expression of P-glycoprotein …

Despite the great benefits of chemotherapy, the ability of tumor cells to acquire
crossresistance to multiple antineoplastic drugs (MDR) results in a drastic reduction in the …

Multidrug resistance (MDR) is one of the main impediments in the treatment of cancers.
MDR cancer cells are resistant to multiple anticancer drugs. One of the major mechanisms of …