In Escherichia coli, proteins found in the periplasm or the outer membrane are exported from
the cytoplasm by the general secretory, Sec, system before they acquire stably folded …

More than one-third of cellular proteomes traffic into and across membranes. Bacteria have
invented several sophisticated secretion systems that guide various proteins to …

The general secretory (Sec) pathway comprises an essential, ubiquitous and universal
export machinery for most proteins that integrate into, or translocate through, the plasma …

Understanding the transport of hydrophilic proteins across biological membranes continues
to be an important undertaking. The general secretory (Sec) pathway in Escherichia coli …

Many proteins synthesized in the cytoplasm ultimately function in non-cytoplasmic locations.
In Escherichia coli, the general secretory (Sec) pathway transports the vast majority of these …

More than a third of all bacterial polypeptides, comprising the 'exportome', are transported to
extracytoplasmic locations. Most of the exportome is targeted and inserts into …

Protein translocation across the bacterial membrane, mediated by the secretory translocon
SecYEG and the SecA ATPase,,,, is enhanced by proton motive force, and membrane …

The major route of protein translocation in bacteria is the so-called general secretion
pathway (Sec-pathway). This route has been extensively studied in Escherichia coli and …

The Sec translocon is a protein-conducting channel that allows polypeptides to be
transferred across or integrated into a membrane. Although protein translocation and …

Significant strides have been made during the past 20 years in our understanding of protein
secretion across the bacterial inner membrane. Specialized chaperones select secretory …