Directed evolution is an important research activity in synthetic biology and biotechnology.
Numerous reports describe the application of tedious mutation/screening cycles for the …

Structural information can help engineer enzymes. Usually, specific amino acids in particular
regions are targeted for functional reconstruction to enhance the catalytic performance …

Enzyme engineering plays a central role in developing efficient biocatalysts for
biotechnology, biomedicine, and life sciences. Apart from classical rational design and …

Computational protein design is becoming a powerful tool for tailoring enzymes for specific
biotechnological applications. When applied to existing enzymes, computational re‐design …

Computational enzyme design has emerged as a promising tool for generating made-to-
order biocatalysts. In addition to improving the reliability of the design cycle, current efforts in …

Directed evolution and rational design are powerful strategies in protein engineering to tailor
enzyme properties to meet the demands in academia and industry. Traditional approaches …

The combinatorial space of an enzyme sequence has astronomical possibilities and
exploring it with contemporary experimental techniques is arduous and often ineffective …

Enzymes are tremendously proficient catalysts, which can be used as extracellular catalysts
for a whole host of processes, from chemical synthesis to the generation of novel biofuels …

The rational design of artificial enzymes, either by applying physico–chemical intuition of
protein structure and function or with the aid of computational methods, is a promising area …

Computational enzyme design is an emerging field that has yielded promising success
stories, but where numerous challenges remain. Accurate methods to rapidly evaluate …