Proteins are the most multifaceted macromolecules in living systems and have various
important functions, including structural, catalytic, sensory, and regulatory functions. Rational …

Abstract Machine learning as a form of artificial intelligence consists of algorithms and
statistical models for improving computer performance for different tasks. Training data are …

In the past decade methods of directed molecular evolution have proven revolutionary in
protein engineering. An increasing number of powerful new combinatorial techniques have …

The availability of tailored enzymes is crucial for the implementation of biocatalysis in
organic chemistry. Enantioselectivity is one key parameter defining the usefulness of an …

The discovery of new enzymes, alongside the push to make chemical processes more
sustainable, has resulted in increased industrial interest in the use of biocatalytic processes …

Directed evolution is being used increasingly in industrial and academic laboratories to
modify and improve commercially important enzymes. Laboratory evolution is thought to …

The (re) design of enzymes to catalyze 'new'reactions is a topic of considerable practical and
intellectual interest. Directed evolution (random mutagenesis followed by …

Enzymes are proteins that catalyse chemical reactions and, as such, have been widely used
to facilitate a variety of natural and industrial processes, dating back to ancient times. In fact …

Modern enzyme development relies to an increasing extent on strategies based on diversity
generation followed by screening for variants with optimised properties. In principle, these …

Natural selection has created optimal catalysts that exhibit their convincing performance
even with a number of sometimes counteracting constraints. Optimal performance of enzyme …