Parkinson's disease, the second major neurodegenerative disease, has created a great
impact on the elder people. Although the mechanisms underlying Parkinson's disease are …

Parkinson's disease (PD) is a neurodegenerative disorder caused by insufficient dopamine
production due to the loss of 50% to 70% of dopaminergic neurons. A shortage of dopamine …

Parkinson's disease (PD) is a chronic neurodegenerative condition which has the second
largest incidence rate among all other neurodegenerative disorders barring Alzheimer's …

A significant amount of evidence suggests that the p38‐mitogen‐activated protein kinase
(MAPK) signalling cascade plays a crucial role in synaptic plasticity and in …

Many studies have revealed a central role of p38 MAPK in neuronal plasticity and the
regulation of long-term changes in synaptic efficacy, such as long-term potentiation (LTP) …

Protein kinases are critical modulators of a variety of cellular signal transduction pathways,
and abnormal phosphorylation events can be a cause or contributor to disease progression …

Inflammation in the central nervous system (CNS) is a common feature of age-related
neurodegenerative diseases. Proinflammatory cytokines, such as IL-1β and TNFα, are …

Accumulating evidence indicates that p38 mitogen-activated protein kinase (MAPK) could
play more than one role in Alzheimer's disease (AD) pathophysiology and that patients …

P38 mitogen-activated protein kinase (MAPK) is a crucial target for chronic inflammatory
diseases. Alzheimer's disease (AD) is characterized by the presence of amyloid plaques …

Mammalian p38 mitogen-activated protein kinases (MAPKs) are activated by a wide range
of cellular stresses as well as in response to inflammatory cytokines. There are four …