Research on the initial phage–host interaction has been conducted on a limited repertoire of
phages and their cognate receptors, such as phage λ and the Escherichia coli LamB (Ec …

Bacteriophages (phages), viruses that infect bacteria, are considered to be highly host-
specific. To add to the knowledge about the evolution and development of bacteriophage …

Bacteriophages, the viruses infecting bacteria, hold great potential for the treatment of
multidrug-resistant bacterial infections and other applications due to their unparalleled …

Studying the coevolutionary dynamics between bacteria and the bacteriophage viruses that
infect them is critical to understanding both microbial diversity and ecosystem functioning …

Highlights•Phage-host interactions have mostly been studied one-by-one using few old
models.•Systematic approaches reveal new molecular mechanisms of phage-host …

As the most abundant microbes on Earth, novel bacteriophages (phages; bacteria-specific
viruses) are readily isolated from environmental samples. However, it remains challenging …

The first step in bacteriophage infection is recognition and binding to the host receptor,
which is mediated by the phage receptor binding protein (RBP). Different RBPs can lead to …

The inherent ability of bacteriophages (phages) to infect specific bacterial hosts makes them
ideal candidates to develop into antimicrobial agents for pathogen-specific remediation in …

The use of bacteriophages as therapeutic agents is hindered by their narrow and specific
host range, and by a lack of the knowledge concerning the molecular mechanism of receptor …

The host range of a bacteriophage is the taxonomic diversity of hosts it can successfully
infect. Host range, one of the central traits to understand in phages, is determined by a range …