How organ size and form are controlled during development is a major question in biology.
Blood vessels have been shown to be essential for early development of the liver and …

Growth and development of embryonic organs goes hand in hand with development of the
vascular system. Blood vessels have been known for centuries to supply nutrients and …

The vertebrate pancreas is comprised of a highly branched tubular epithelium, which is
intimately associated with an extensive and specialized vasculature. While we know a great …

Blood vessels course through organs, providing them with essential nutrient and gaseous
exchange. However, the vasculature has also been shown to provide non-nutritional signals …

Endothelial cells are required to initiate pancreas development from the endoderm. They
also control the function of endocrine islets after birth. Here we investigate in developing …

Blood vessels form a highly branched, interconnected, and largely stereotyped network of
tubes that sustains every organ and tissue in vertebrates. How vessels come to take on their …

Blood vessels supply developing organs with metabolic sustenance. Here, we demonstrate
a role for blood vessels as a source of developmental signals during pancreatic …

Understanding the tissue interactions that induce pancreatic progenitor cells from the
embryonic endoderm provides insights into congenital malformations, tissue repair, and …

Liver and pancreas initially develop by budding from the embryonic endoderm. The
formation of these organs coincides with the appearance of endothelial cells (ECs) adjacent …

There is a reciprocal interaction between pancreatic islet cells and vascular endothelial cells
(EC) in which EC-derived signals promote islet cell differentiation and islet development …