Known as highly efficient metallodrugs that have been clinically used to treat various types
of cancers, cisplatin and its analogues have attracted and inspired extensive interest in the …

The fast-growing body of experimental data on metalloenzymes and organometallic
compounds is fostering the exploitation of metal–ligand interactions for the design of new …

Metal-based compounds form a promising class of therapeutic agents, whose mechanisms
of action still need to be elucidated, and that are in general prone to undergo extensive …

Coordination compounds on account of distinctive features of metal ions that include
variable oxidation states, diverse range of geometries and coordination numbers …

Metal complexes have been the subject of numerous investigations in oncology but, despite
the plethora of newly synthesized compounds, their precise mechanisms of action remain …

This review illustrates notable recent progress in the field of medicinal bioinorganic
chemistry as many new approaches to the design of innovative metal-based anticancer …

The clinical application and development of potent metal-based drugs relies heavily on a full
understanding of their underlying molecular mechanisms. The emerging research field of …

The discovery of the medicinal properties of platinum complexes has fueled the design and
synthesis of new anticancer metallodrugs endowed with unique modes of action (MoA) …

The great clinical success of cisplatin and its derivatives has convinced people that metal
complexes could play a more significant role in human cancer therapy. However, targeting …

Introduction: The occurrence of metal ions in biomolecules is required to exert vital cellular
functions. Metal-containing biomolecules can be modulated by small-molecule inhibitors …