Neohesperidin dihydrochalcone down-regulates MyD88-dependent and-independent signaling by inhibiting endotoxin-induced trafficking of TLR4 to lipid rafts

X Xia, J Fu, X Song, Q Shi, C Su, E Song… - Free Radical Biology and …, 2015 - Elsevier
Fulminant hepatic failure (FHF) is a lethal clinical syndrome characterized by the activation
of macrophages and the increased production of inflammatory mediators. The purpose of …

Tetrandrine attenuates lipopolysaccharide-induced fulminant hepatic failure in D-galactosamine-sensitized mice

X Gong, F Luo, L Zhang, H Li, M Wu, X Li… - International …, 2010 - Elsevier
Fulminant hepatic failure (FHF) remains an extremely poor prognosis and high mortality;
better treatments are urgently needed. Tetrandrine (TET), a traditional anti-inflammatory …

Ethyl 2-succinate-anthraquinone attenuates inflammatory response and oxidative stress via regulating NLRP3 signaling pathway

B Feng, X Zhao, W Zhao, H Jiang, Z Ren… - Frontiers in …, 2021 - frontiersin.org
Aloe-emodin widely possesses antibacterial, anti-inflammatory, antioxidant, antiviral, and
anti-infectious properties. This study investigated the effect of ethyl 2-succinate …

[HTML][HTML] Lupeol ameliorates LPS/D-GalN induced acute hepatic damage by suppressing inflammation and oxidative stress through TGFβ1-Nrf2 signal pathway

S Huang, C Mo, T Zeng, Y Lai, C Zhou, S Xie… - Aging (Albany …, 2021 - ncbi.nlm.nih.gov
Acute hepatic damage is a severe condition characterized by inflammation and oxidative
stress, which is a serious threat to people's life and health. But there are few effective …

β-Caryophyllene alleviates D-galactosamine and lipopolysaccharide-induced hepatic injury through suppression of the TLR4 and RAGE signaling pathways

HI Cho, JM Hong, JW Choi, HS Choi, JH Kwak… - European Journal of …, 2015 - Elsevier
Agastache rugosa (A. rugosa, Labiatae), a perennial herb spread throughout Korean fields,
is widely consumed as a wild edible vegetable and is used in folk medicine. This study …

Dihydroquercetin (DHQ) ameliorated concanavalin A-induced mouse experimental fulminant hepatitis and enhanced HO-1 expression through MAPK/Nrf2 antioxidant …

M Zhao, J Chen, P Zhu, M Fujino, T Takahara… - International …, 2015 - Elsevier
Autoimmune hepatitis represents a ubiquitous human health problem and has a poor
prognosis. Dihydroquercetin (DHQ), a well-known antioxidant, significantly inhibits fulminant …

Nrf2 signaling and autophagy are complementary in protecting lipopolysaccharide/d-galactosamine-induced acute liver injury by licochalcone A

H Lv, H Yang, Z Wang, H Feng, X Deng, G Cheng… - Cell death & …, 2019 - nature.com
Abstract Licochalcone A (Lico A), isolated from Xinjiang licorice Glycyrrhiza inflate, has been
shown to have antioxidative potential via the activation of nuclear factor-erythroid 2-related …

Sesamin ameliorates lipopolysaccharide/d-galactosamine-induced fulminant hepatic failure by suppression of Toll-like receptor 4 signaling in mice

L Ma, X Gong, G Kuang, R Jiang, R Chen… - … and biophysical research …, 2015 - Elsevier
Sesamin has been described to exert anti-oxidant and anti-inflammatory properties. In
present study, we investigated the potential effects and mechanisms of sesamin on …

Licochalcone A protects against LPS‐induced inflammation and acute lung injury by directly binding with myeloid differentiation factor 2 (MD2)

W Zhu, M Wang, L Jin, B Yang, B Bai… - British Journal of …, 2023 - Wiley Online Library
Background and Purpose Acute lung injury (ALI)/acute respiratory distress syndrome
(ARDS) is a challenging clinical syndrome that leads to various respiratory sequelae and …

Reduced hepatic injury in toll-like receptor 4–deficient mice following d-galactosamine/lipopolysaccharide-induced fulminant hepatic failure

Z Ben Ari, O Avlas, O Pappo, V Zilbermints… - Cellular Physiology and …, 2012 - karger.com
Liver transplantation is the only therapy of proven benefit in fulminant hepatic failure (FHF).
Lipopolysaccharide (LPS), D-galactosamine (GalN)-induced FHF is a well established …