Testis morphogenesis is a highly orchestrated process involving lineage determination of
male germ cells and somatic cell types. Although the origin and differentiation of germ cells …

Human testis development in prenatal life involves complex changes in germline and
somatic cell identity. To better understand, we profiled and analyzed∼ 32,500 single-cell …

During the differentiation of the mammalian embryonic testis, two compartments are defined:
the testis cords and the interstitium. The testis cords give rise to the adult seminiferous …

Leydig cells are the steroidogenic lineage of the mammalian testis that produces
testosterone, a key hormone required throughout male fetal and adult life for virilization and …

Gonadal sex determination represents a unique model for studying cell fate decisions.
However, a complete understanding of the different cell lineages forming the developing …

Development of testes in the mammalian embryo requires the formation and assembly of
several cell types that allow these organs to achieve their roles in male reproduction and …

Testicular Leydig cells play pivotal roles in masculinization of organisms by producing
androgens. At least two distinct Leydig cell populations sequentially emerge in the …

Leydig cells (LCs) are the major androgen-producing cells in the testis. They arise from
steroidogenic progenitors (SPs), whose origins, maintenance, and differentiation dynamics …

Fetal and adult Leydig cells develop in mammalian prenatal and postnatal testes,
respectively. In mice, fetal Leydig cells (FLCs) emerge in the interstitial space of the testis at …

Spermatogonial stem cells (SSCs) fuel the production of male germ cells but the
mechanisms behind SSC self-renewal, proliferation, and differentiation are still poorly …