Progress in the development of small molecular inhibitors of focal adhesion kinase (FAK)

Y Lu, H Sun - Journal of Medicinal Chemistry, 2020 - ACS Publications
Focal adhesion kinase (FAK) is a nonreceptor intracellular tyrosine kinase that plays an
essential role in cancer cell adhesion, survival, proliferation, and migration through both its …

Drug discovery targeting focal adhesion kinase (FAK) as a promising cancer therapy

XJ Pang, XJ Liu, Y Liu, WB Liu, YR Li, GX Yu, XY Tian… - Molecules, 2021 - mdpi.com
FAK is a nonreceptor intracellular tyrosine kinase which plays an important biological
function. Many studies have found that FAK is overexpressed in many human cancer cell …

Focal adhesion kinase—An emerging viable target in cancer and development of focal adhesion kinase inhibitors

A Chauhan, T Khan - Chemical biology & drug design, 2021 - Wiley Online Library
Focal adhesion kinase (FAK) is a non‐receptor tyrosine kinase located at the extracellular
matrix cell adhesion site. This kinase mediates downstream signalling cascades on the cell …

Focal adhesion kinase inhibitors, a heavy punch to cancer

Y Wu, N Li, C Ye, X Jiang, H Luo, B Zhang, Y Zhang… - Discover Oncology, 2021 - Springer
Kinases are the ideal druggable targets for diseases and especially were highlighted on
cancer therapy. Focal adhesion kinase (FAK) is a non-receptor tyrosine kinase and its …

FAK inhibitors in Cancer, a patent review

PC Lv, AQ Jiang, WM Zhang, HL Zhu - Expert opinion on …, 2018 - Taylor & Francis
Introduction: Focal adhesion kinase (FAK) is a non-receptor tyrosine kinase that localizes at
sites of cell adhesion to the extracellular matrix (ECM) and mediates signalling events …

The development of FAK inhibitors: a five-year update

A Spallarossa, B Tasso, E Russo, C Villa… - International Journal of …, 2022 - mdpi.com
Focal adhesion kinase (FAK) is a non-receptor tyrosine kinase over-expressed in different
solid cancers. In recent years, FAK has been recognized as a new target for the …

Focal adhesion kinase: from biological functions to therapeutic strategies

X Tan, Y Yan, B Song, S Zhu, Q Mei, K Wu - Experimental Hematology & …, 2023 - Springer
Focal adhesion kinase (FAK), a nonreceptor cytoplasmic tyrosine kinase, is a vital
participant in primary cellular functions, such as proliferation, survival, migration, and …

Targeting focal adhesion kinase using inhibitors of protein-protein interactions

A Mousson, E Sick, P Carl, D Dujardin, J De Mey… - Cancers, 2018 - mdpi.com
Focal adhesion kinase (FAK) is a cytoplasmic non-receptor protein tyrosine kinase that is
overexpressed and activated in many human cancers. FAK transmits signals to a wide range …

Focal adhesion kinase as a cancer therapy target

VM Golubovskaya - Anti-Cancer Agents in Medicinal …, 2010 - ingentaconnect.com
Focal adhesion kinase (FAK) is a non-receptor tyrosine kinase that resides at the sites of at
focal adhesions. The 125 kDa FAK protein is encoded by the FAK gene located on human …

FAK in cancer: from mechanisms to therapeutic strategies

HH Chuang, YY Zhen, YC Tsai, CH Chuang… - International journal of …, 2022 - mdpi.com
Focal adhesion kinase (FAK), a non-receptor tyrosine kinase, is overexpressed and
activated in many cancer types. FAK regulates diverse cellular processes, including growth …