Statins for primary prevention of cardiovascular disease in elderly patients: systematic review and meta-analysis

M Teng, L Lin, YJ Zhao, AL Khoo, BR Davis, QW Yong… - Drugs & aging, 2015 - Springer
Background Statins have been shown to be beneficial in primary and secondary prevention
settings; however, their role in the elderly remains a clinical conundrum, given that age …

[HTML][HTML] Association of statin use in older people primary prevention group with risk of cardiovascular events and mortality: a systematic review and meta-analysis of …

K Awad, M Mohammed, MM Zaki, AI Abushouk… - BMC medicine, 2021 - Springer
Background Current evidence from randomized controlled trials on statins for primary
prevention of cardiovascular disease (CVD) in older people, especially those aged> 75 …

Statin and clinical outcomes of primary prevention in individuals aged> 75 years: The SCOPE-75 study

K Kim, CJ Lee, CY Shim, JS Kim, BK Kim, S Park… - Atherosclerosis, 2019 - Elsevier
Background and aims Limited data is available on the benefit of statin for primary prevention
in the elderly. The aim of this study is to investigate whether statin for primary prevention is …

[HTML][HTML] Statins for primary cardiovascular prevention in the elderly

J Pedro-Botet, E Climent, JJ Chillarón… - Journal of geriatric …, 2015 - ncbi.nlm.nih.gov
The elderly population is increasing worldwide, with subjects> 65 years of age constituting
the fastest-growing age group. Furthermore, the elderly face the greatest risk and burden of …

The safety and tolerability of statin therapy in primary prevention in older adults: a systematic review and meta-analysis

Z Zhou, L Albarqouni, AJ Curtis, M Breslin, M Nelson - Drugs & aging, 2020 - Springer
Purpose The use of statins in the primary prevention of cardiovascular disease (CVD) is
increasing in older adults. Nonetheless, good clinical evidence for the safety and tolerability …

Real-life benefits of statins for cardiovascular prevention in elderly subjects: a population-based cohort study

J Bezin, N Moore, Y Mansiaux, PG Steg… - The American Journal of …, 2019 - Elsevier
Objectives The benefits of initiating statins in the elderly remains debated. We evaluated the
effects of initiating statins in the elderly, according to cardiovascular risk. Methods This …

Effectiveness of statins for the primary prevention of cardiovascular disease in the Asian elderly population

YW Lin, CC Wang, CC Wu, YT Hsu, FJ Lin - International Journal of …, 2023 - Elsevier
Background Population aging is a global trend, and the elderly have a higher risk of
atherosclerotic cardiovascular disease (ASCVD) and related mortality. Statins have been …

Benefits and Risks Associated With Statin Therapy for Primary Prevention in Old and Very Old Adults: Real-World Evidence From a Target Trial Emulation Study

W Xu, AL Lee, CLK Lam, G Danaei… - Annals of Internal …, 2024 - acpjournals.org
Background: There is little consensus on using statins for primary prevention of
cardiovascular diseases (CVDs) and all-cause mortality in adults aged 75 years or older due …

Statins for primary prevention in adults aged 75 years and older: a nationwide population-based case-control study

JE Jun, IJ Cho, K Han, IK Jeong, KJ Ahn, HY Chung… - Atherosclerosis, 2019 - Elsevier
Background and aims There is inadequate evidence to establish statin treatment for primary
prevention in the elderly. This study evaluated whether statins are beneficial for primary …

Efficacy and safety of statin monotherapy in older adults: a meta-analysis

CGP Roberts, E Guallar… - The Journals of …, 2007 - academic.oup.com
Background. Statin therapy significantly reduces cardiovascular events. Older patients,
however, are less likely to be prescribed statins than younger patients due to concern over …