Elevated resting blood pressure is associated with decreased pain sensitivity in both
animals and humans. Recent evidence suggests that this relationship may be mediated by …

Objective: Acute pain sensitivity is reduced in clinical hypertension, but the precise
relationship between pain perception and altered blood pressure control is not well …

Pain sensitivity decreases with increasing resting blood pressure. This blood pressure–pain
interaction may be mediated by endogenous opioids which have been shown to affect both …

Resting blood pressure is inversely correlated with acute pain sensitivity in healthy
normotensives. This study tested:(1) whether endogenous opioid activity is necessary for …

This study used a placebo-controlled, between-subjects opioid blockade design to evaluate
endogenous opioid involvement in the hypoalgesia associated with elevated resting blood …

THE JOURNAL OF CLINICAL HYPERTENSION VOL. V NO. V SEPTEMBER/OCTOBER
2003 360 range of blood pressure. 7 There is also evidence that hypalgesia may precede …

This double blind, placebo-controlled study examined the effects of an opiate antagonist,
naltrexone, on nociceptive flexion reflex (NFR) thresholds and subjective pain in individuals …

A 2003 study suggested that there are age differences in diffuse noxious inhibitory controls
(DNIC), a form of endogenous pain inhibition. The present report describes a followup study …

Hypertension has been found to be related to decreased sensitivity to painful stimuli. The
current study explored whether this relationship extends into the normotensive range of …

An opioid mechanism may help explain hypertensive hypoalgesia. A double-blind placebo-
controlled design compared the effects of opioid blockade (naltrexone) and placebo on …