Heart failure (HF) is a complex syndrome characterized by impaired cardiac function. Two
common subtypes of HF include heart failure with preserved ejection fraction (HFpEF) and …

Mitochondria require nitric oxide (NO) to exert a delicate control of metabolic rate as well as
to regulate life functions, cell cycle activation and arrest, and apoptosis. All activities depend …

Heart failure and many of the conditions that predispose to heart failure are associated with
oxidative stress. This is considered to be important in the pathophysiology of the condition …

Endogenous formation of nitric oxide (NO) and related nitrogen oxides in the vascular
system is critical to regulation of multiple physiological functions. An imbalance in the …

Aims: Research into right ventricular (RV) physiology and identification of pathomechanisms
underlying RV failure have been neglected for many years, because function of the RV is …

Endothelial dysfunction, a critical component in the progression of heart failure, may result
from increased oxidative stress, secondary to activation of the adrenergic and the renin …

The only known function of the Nox family of NADPH oxidases is the production of reactive
oxygen species (ROS). Some Nox enzymes show high tissue-specific expression and the …

Reactive oxygen species (ROS) are generated by several different cellular sources, and
their accumulation within the myocardium is widely considered to cause harmful oxidative …

Nitric oxide (NO) has been implicated in several cellular processes as a signaling molecule
and also as a source of reactive nitrogen species (RNS). NO is produced by three …

Increased oxidative stress is a major contributor to the development and progression of
heart failure, however, our knowledge on the role of the distinct NADPH oxidase (NOX) …