BACKGROUND: The effectiveness of aerosol drug delivery during mechanical ventilation is
influenced by the patient, ventilator, and nebulizer variables. The impact of nebulizer type …

Aerosolized medications are routinely used for the treatment of critically ill patients. This
paper reviews aerosol delivery devices with a focus on issues related to their performance in …

Patients with obstructive lung disease often require ventilatory support via invasive or
noninvasive mechanical ventilation, depending on the severity of the exacerbation. The use …

OBJECTIVE: Four-hour comparison of the bronchodilator response of albuterol administered
via metered-dose inhaler (MDI) with spacer versus small-volume nebulizer (SVN) to …

Successful bronchodilator therapy with a metered-dose inhaler (MDI) in intubated,
mechanically ventilated patients requires adequate delivery of aerosol to the lower …

Background Volume-controlled ventilation has been suggested to optimize lung deposition
during nebulization although promoting spontaneous ventilation is targeted to avoid …

Purpose Unlike in the outpatient setting, delivery of aerosols to critically ill patients may be
considered complex, particularly in ventilated patients, and benefits remain to be proven …

Background Aerosol delivery via mechanical ventilation has been reported to vary
significantly among different intensive care units (ICU). The optimal technique for using each …

In nonintubated patients, metered-dose inhalers (MDIs) are accepted as the most
convenient, efficient, and cost effective method of administering inhaled bronchodilators …

Aerosol therapy in mechanically ventilated patients delivers drug particles driven by
inspiratory gases. Bronchodilators, steroids, mucolytics, polymyxins and aminoglycosides …