Background Bronchodilator responsiveness (BDR) is commonly used in the diagnosis of
lung disease. Although small airways dysfunction is a feature of asthma and COPD …

Background Bronchodilator responsiveness (BDR) using FEV1 is often utilised to separate
COPD patients from asthmatics, although it can be present in some COPD patients. With the …

Background Bronchodilator responsiveness (BDR) in obstructive lung disease varies over
time and may be associated with distinct clinical features. Research Question Is consistent …

Identification of pathologic changes in early and mild obstructive lung disease has shown
the importance of the small airways and their contribution to symptoms. Indeed, significant …

The clinical relevance of the small airways in persistent asthma has been gaining greater
recognition in recent years [ 1]. Studies have shown that a significant proportion of …

Background Asthma is a common, heterogeneous disease that is characterised by chronic
airway inflammation and variable expiratory airflow limitation. Current guidelines use …

It is increasingly acknowledged that delays in the diagnosis of chronic inflammatory lung
conditions have hampered our understanding of pathogenesis and thus our ability to design …

Background We investigated whether a relationship between small airways dysfunction and
bronchial hyperresponsiveness (BHR), expressed both in terms of ease of airway narrowing …

Traditionally, asthma has been considered a disease that predominantly involves the large
airways. Today, this concept is being challenged, and increasing evidence has become …

Rationale: The prevalence and diagnostic utility of bronchodilator responsiveness (BDR) in
a real-life setting is unclear. Objective: To explore this uncertainty in patients aged⩾ 12 …