Myocardial contractile dysfunction in diabetic cardiomyocytes is a significant promoter of
heart failure. Herein, we investigated the effect of icariin, a flavonoid monomer isolated from …

Ethnopharmacological relevance Aconite is a processed product of seminal root of
perennial herbaceous plant Aconitum Carmichaclii Debx. of Ranunculaceae. It has the …

To investigate the effects and the underlying mechanisms of salidroside on diabetic
cardiomyopathy, diabetes was induced in mice by a long‐term high‐fat diet and a low‐dose …

Aims/hypothesis Diabetic cardiomyopathy, characterised by increased oxidative damage
and mitochondrial dysfunction, contributes to the increased risk of heart failure in individuals …

Background and Purpose Icariin, a major active ingredient in traditional Chinese medicines,
is attracting increasing attention because of its unique pharmacological effects against …

Insulin resistance contributes to the high prevalence of type 2 diabetes mellitus, leading to
cardiac anomalies. Emerging evidence depicts a pivotal role for mitochondrial injury in …

Background and Purpose: Mitochondrial dysfunction remains the crucial cause for many
heart diseases including diabetic cardiomyopathy (DCM). Sirtuin-3 (SIRT-3) is a protein …

Myocardial fibrosis represents the primary pathological change associated with diabetic
cardiomyopathy and heart failure, and it leads to decreased myocardial compliance with …

Background: Type II diabetes (T2D)-induced cardiomyocyte hypertrophy is closely linked to
the impairment of mitochondrial function. Berberine has been shown to be a promising effect …

Aims: This study aims to explore the efficacy of punicalagin (PG) on diabetic cardiomyopathy
(DCM), with a specific focus on the mechanisms underlying the effects of PG on …