The discovery of the archetypal adipocytokine leptin and how it regulates energy
homeostasis have represented breakthroughs in our understanding of the endocrine …

Leptin is an adipocyte-derived hormone/cytokine that links nutritional status with
neuroendocrine and immune functions. In humans, leptin influences energy homeostasis …

Leptin, a 16kDa non-glycosylated polypeptide produced primarily by adipocytes and
released into the systemic circulation, exerts a multitude of regulatory functions including …

The past twenty years of research on leptin has provided crucial information on the link
between metabolic state and immune system function. Adipocytes influence not only the …

Since its discovery as an adipocyte-secreted hormone, leptin has been found to impact food
intake, energy homeostasis, and metabolism through its effects on the central nervous …

This issue of the journal Metabolism celebrates the 20 years since the discovery of the
prototypical adipose tissue secreted hormone leptin [1],[2],[3],[4],[5],[6],[7],[8],[9]. Leptin has …

Leptin is a critical mediator of the immune response to changes in overall nutrition. Leptin is
produced by adipocytes in proportion to adipose tissue mass and is therefore increased in …

Initially described as an antiobesity hormone, leptin has subsequently been shown also to
influence hematopoiesis, thermogenesis, reproduction, angiogenesis, and immune …

It has recently become apparent that several molecules involved in the control of metabolism
also play an important function in the regulation of immune responses. Among those …

After its discovery as a key controller of metabolic function, leptin has been later extensively
implicated in additional functions including important modulatory activities on the innate and …