Building and re-building the heart by cardiomyocyte proliferation
The adult human heart does not regenerate significant amounts of lost tissue after injury.
Rather than making new, functional muscle, human hearts are prone to scarring and …
Rather than making new, functional muscle, human hearts are prone to scarring and …
Cardiomyocyte proliferation in cardiac development and regeneration: a guide to methodologies and interpretations
The newt and the zebrafish have the ability to regenerate many of their tissues and organs
including the heart. Thus, a major goal in experimental medicine is to elucidate the …
including the heart. Thus, a major goal in experimental medicine is to elucidate the …
Multimodal regulation of cardiac myocyte proliferation
Efficient cardiac regeneration is closely associated with the ability of cardiac myocytes to
proliferate. Fetal or neonatal mouse hearts containing proliferating cardiac myocytes …
proliferate. Fetal or neonatal mouse hearts containing proliferating cardiac myocytes …
Cardiac muscle regeneration: lessons from development
M Mercola, P Ruiz-Lozano… - Genes & …, 2011 - genesdev.cshlp.org
The adult human heart is an ideal target for regenerative intervention since it does not
functionally restore itself after injury yet has a modest regenerative capacity that could be …
functionally restore itself after injury yet has a modest regenerative capacity that could be …
[HTML][HTML] Cardiac regeneration based on mechanisms of cardiomyocyte proliferation and differentiation
Cardiomyocyte proliferation and progenitor differentiation are endogenous mechanisms of
myocardial development. Cardiomyocytes continue to proliferate in mammals for part of post …
myocardial development. Cardiomyocytes continue to proliferate in mammals for part of post …
Features of cardiomyocyte proliferation and its potential for cardiac regeneration
MJ van Amerongen, FB Engel - Journal of cellular and …, 2008 - Wiley Online Library
The human heart does not regenerate. Instead, following injury, human hearts scar. The loss
of contractile tissue contributes significantly to morbidity and mortality. In contrast to humans …
of contractile tissue contributes significantly to morbidity and mortality. In contrast to humans …
[HTML][HTML] A neonatal blueprint for cardiac regeneration
ER Porrello, EN Olson - Stem cell research, 2014 - Elsevier
Adult mammals undergo minimal regeneration following cardiac injury, which severely
compromises cardiac function and contributes to the ongoing burden of heart failure. In …
compromises cardiac function and contributes to the ongoing burden of heart failure. In …
Cardiomyocyte regeneration: a consensus statement
Circulation. 2017; 136: 680–686. DOI: 10.1161/CIRCULATIONAHA. 117.029343 August 15,
2017 681 proliferation. 5 It remains unclear whether this regenerative window exists in large …
2017 681 proliferation. 5 It remains unclear whether this regenerative window exists in large …
Cardiac regenerative capacity and mechanisms
The heart holds the monumental yet monotonous task of maintaining circulation. Although
cardiac function is critical to other organs and to life itself, mammals are not equipped with …
cardiac function is critical to other organs and to life itself, mammals are not equipped with …
[HTML][HTML] Dedifferentiation and proliferation of mammalian cardiomyocytes
Background It has long been thought that mammalian cardiomyocytes are terminally-
differentiated and unable to proliferate. However, myocytes in more primitive animals such …
differentiated and unable to proliferate. However, myocytes in more primitive animals such …