During the past two decades, the field of mammalian myocardial regeneration has grown
dramatically, and with this expanded interest comes increasing claims of experimental …

The heart is the first organ to form during embryonic development. Given the complex nature
of cardiac differentiation and morphogenesis, it is not surprising that some form of congenital …

Rationale: Neonatal mice have the capacity to regenerate their hearts in response to injury,
but this potential is lost after the first week of life. The transcriptional changes that underpin …

Endocardial cells are specialized endothelial cells that form the innermost layer of the heart
wall. By virtue of genetic lineage–tracing technology, many of the unexpected roles of …

The latest discoveries and advanced knowledge in the fields of stem cell biology and
developmental cardiology hold great promise for cardiac regenerative medicine, enabling …

Adult mammals are unable to regenerate their hearts after cardiac injury, largely due to the
incapacity of cardiomyocytes (CMs) to undergo cell division. However, mammalian …

Cardiomyocytes (CMs) lost during cardiac injury and heart failure (HF) cannot be replaced
due to their limited proliferative capacity. Regenerating the failing heart by promoting CM …

Cardiac fibroblasts are the most abundant cell type in the mammalian heart and comprise
approximately two-thirds of the total number of cardiac cell types. During development …

Emerging data in the field of cardiac development as well as repair and regeneration
indicate a complex and important interplay between endocardial, epicardial, and …

Heart failure plagues industrialized nations, killing more people than any other disease. It
usually results from a deficiency of specialized cardiac muscle cells known as …