Cognitive function of rats treated with saline (control), THA (8 mg/kg, ip), scopolamine (5
mg/kg, ip), or a combination of THA (8 mg/kg) and scopolamine (5 mg/kg) was tested in the …

Alzheimer's disease (AD) is a neurodegenerative disorder accompanied by the loss and
apoptosis of neurons. Neurons abnormally enter the cell cycle, which results in neuronal …

Rationale The mechanism involved in AD is complex, which has prompted to develop
compounds that could simultaneously interact with several potential targets. Here, we report …

Icariin (ICA), a prenylated flavanol glycoside present in abundant quantities in Epimedium
sagittatum, has shown promise in the treatment and prevention of Alzheimer's disease …

Memory loss and cognition decline are the main clinical manifestations of Alzheimer's
disease (AD). Amyloid β protein (Aβ) aggregated in the brain is one of the key pathological …

Background: Currently, there is no conclusive cure for Alzheimer's disease (AD) and existing
treatments mainly offer symptomatic relief. Dysfunction of the cholinergic system plays an …

Pyrrolidine dithiocarbamate (PDTC) is a clinically tolerated inhibitor of nuclear factor-κB (NF-
κB), antioxidant and antiinflammatory agent, which provides protection in brain ischemia …

Alzheimer's disease (AD) is a progressive and neurodegenerative disorder and one of the
current therapies involves strengthening the cholinergic tone in central synapses …

Cornuside has been discovered to improve learning and memory in AD mice, however, its
underlying mechanism was not fully understood. In the present study, we established an AD …

Alzheimer's disease (AD) is a neurodegenerative disease. Senile plaques and intracellular
neurofibrillary tangles are pathological hallmarks of AD. Recent studies have described the …