Aberrant glycosylation, a common feature associated with malignancy, has been implicated
in important events during cancer progression. Our understanding of the role of glycans in …

Tumour metastasis is the main cause of cancer related deaths. Metastasis is an intricate
multi-step process that requires the acquisition of several cancer cell features, including the …

Malignant transformation of cells is associated with aberrant glycosylation presented on the
cell-surface. Commonly observed changes in glycan structures during malignancy …

Glycans are part of the essential components of a cell. These compounds play a
fundamental role in several physiopathological processes, including cell differentiation …

Cell surface carbohydrates (known as glycans) are often aberrantly expressed or found at
atypical levels in cancer. Glycans can impact all steps in tumour progression, from malignant …

The immunomodulatory family of Siglecs recognizes sialic acid-containing glycans as “self”,
which is exploited in cancer for immune evasion. The biochemical nature of Siglec ligands …

Simple Summary Hyperglycosylated cancer cells are often decorated with abundant sialic
acids, which are recognized by Sialic acid binding immunoglobulin type lectins (Siglecs) …

Cancer cells commonly display aberrant surface glycans and related glycoconjugate
scaffolds. Compared with their normal counterparts, cancer cell glycans are variably …

Along with the discovery of tumor-driven inflammatory pathways, there has been a
considerable progress over the past 10 years in understanding the mechanisms leading to …

This review provides insights on the impact of glycosylation in cancer biology and its
influence in the current approaches of targeted cancer therapies in the clinical setting. The …