Intestinal epithelial cells absorb nutrients, respond to microbes, function as a barrier and
help to coordinate immune responses. Here we report profiling of 53,193 individual …

The cellular landscape of the human intestinal tract is dynamic throughout life, developing in
utero and changing in response to functional requirements and environmental exposures …

The intestine is a complex organ that promotes digestion, extracts nutrients, participates in
immune surveillance, maintains critical symbiotic relationships with microbiota and affects …

Our knowledge of species and functional composition of the human gut microbiome is
rapidly increasing, but it is still based on very few cohorts and little is known about variation …

The colonic epithelium facilitates host–microorganism interactions to control mucosal
immunity, coordinate nutrient recycling and form a mucus barrier. Breakdown of the …

Peripheral mechanisms preventing autoimmunity and maintaining tolerance to commensal
microbiota involve CD4+ Foxp3+ regulatory T (Treg) cells, generated in the thymus or …

Correct development and maturation of the enteric nervous system (ENS) is critical for
survival. At birth, the ENS is immature and requires considerable refinement to exert its …

Inflammatory bowel diseases, which include Crohn's disease and ulcerative colitis, affect
several million individuals worldwide. Crohn's disease and ulcerative colitis are complex …

Humans and their microbiota have coevolved a mutually beneficial relationship in which the
human host provides a hospitable environment for the microorganisms and the microbiota …

Understanding the development and function of an organ requires the characterization of all
of its cell types. Traditional methods for visualizing and isolating subpopulations of cells are …