Minireview: autophagy in pancreatic β-cells and its implication in diabetes
H Watada, Y Fujitani - Molecular Endocrinology, 2015 - academic.oup.com
Autophagy is a conserved system for the degradation of cytoplasmic proteins and
organelles. During insulin resistance, in which insulin secretion is enhanced and β-cell …
organelles. During insulin resistance, in which insulin secretion is enhanced and β-cell …
Autophagy and disease
A Thorburn - Journal of biological chemistry, 2018 - ASBMB
As outlined in the accompanying Minireviews, autophagy is a complicated and highly
regulated process that delivers cellular material to lysosomes for degrading, recycling, and …
regulated process that delivers cellular material to lysosomes for degrading, recycling, and …
Autophagy and inflammation: a special review issue
V Deretic, DJ Klionsky - Autophagy, 2018 - Taylor & Francis
Macroautophagy/autophagy is a fundamental intracellular homeostatic process that is of
interest both for its basic biology and for its effect on human physiology in a wide spectrum of …
interest both for its basic biology and for its effect on human physiology in a wide spectrum of …
[PDF][PDF] Defective hepatic autophagy in obesity promotes ER stress and causes insulin resistance
Autophagy is a homeostatic process involved in the bulk degradation of cytoplasmic
components, including damaged organelles and proteins. In both genetic and dietary …
components, including damaged organelles and proteins. In both genetic and dietary …
Aging: central role for autophagy and the lysosomal degradative system
YS Rajawat, Z Hilioti, I Bossis - Ageing research reviews, 2009 - Elsevier
The lysosomal network is the major intracellular proteolytic system accounting for more than
98% of long-lived bulk protein degradation and recycling particularly in tissues such as liver …
98% of long-lived bulk protein degradation and recycling particularly in tissues such as liver …
[PDF][PDF] Autophagy ablation in adipocytes induces insulin resistance and reveals roles for lipid peroxide and Nrf2 signaling in adipose-liver crosstalk
J Cai, KM Pires, M Ferhat, B Chaurasia, MA Buffolo… - Cell reports, 2018 - cell.com
Autophagy is a homeostatic cellular process involved in the degradation of long-lived or
damaged cellular components. The role of autophagy in adipogenesis is well recognized …
damaged cellular components. The role of autophagy in adipogenesis is well recognized …
Autophagy regulates inflammation in adipocytes
T Yoshizaki, C Kusunoki, M Kondo, M Yasuda… - Biochemical and …, 2012 - Elsevier
Autophagy is an essential process for both the maintenance and the survival of cells, with
homeostatic low levels of autophagy being critical for intracellular organelles and proteins …
homeostatic low levels of autophagy being critical for intracellular organelles and proteins …
Autophagy is important in islet homeostasis and compensatory increase of beta cell mass in response to high-fat diet
C Ebato, T Uchida, M Arakawa, M Komatsu, T Ueno… - Cell metabolism, 2008 - cell.com
Autophagy is an evolutionarily conserved machinery for bulk degradation of cytoplasmic
components. Here, we report upregulation of autophagosome formation in pancreatic beta …
components. Here, we report upregulation of autophagosome formation in pancreatic beta …
[HTML][HTML] Autophagy: renovation of cells and tissues
N Mizushima, M Komatsu - Cell, 2011 - cell.com
Autophagy is the major intracellular degradation system by which cytoplasmic materials are
delivered to and degraded in the lysosome. However, the purpose of autophagy is not the …
delivered to and degraded in the lysosome. However, the purpose of autophagy is not the …
[HTML][HTML] Autophagy: principles and significance in health and disease
V Todde, M Veenhuis, IJ van Der Klei - Biochimica et Biophysica Acta (BBA …, 2009 - Elsevier
Degradation processes are important for optimal functioning of eukaryotic cells. The two
major protein degradation pathways in eukaryotes are the ubiquitin–proteasome pathway …
major protein degradation pathways in eukaryotes are the ubiquitin–proteasome pathway …