Cytokines are critical mediators of protective host responses, including defense against
microbial invasion and tumorigenesis. However, the production of specific proinflammatory …

Cytokines which comprise of a family of proteins—interleukins, lymphokines, monokines,
interferons, and chemokines, are important components of the immune system. They act in …

Proinflammatory cytokines are potent mediators of numerous biological processes and are
tightly regulated in the body. Chronic uncontrolled levels of such cytokines can initiate and …

Although cytokines are critical in maintaining normal physiology, excessive production of
these proteins can lead to pathological consequences. Inhibitors of cytokine production or …

Publisher Summary This chapter illustrates that cytokines are important therapeutic targets
in a range of diseases and has given an overview of current approaches being used to …

Inflammation is mediated by a variety of soluble factors, including a group of secreted
polypeptides known as cytokines. Inflammatory cytokines can be divided into two groups …

This commentary is an introduction to a special issue on “Latest Developments in the
Treatment of Inflammation”. It outlines some key events in the inflammatory response to …

Anti-cytokine therapy has promoted a revolution in the treatment of several inflammatory
disorders during the past 10 years. Despite their medical and commercial success, they …

Cytokines are secreted or membrane-presented molecules that mediate broad cellular
functions, including development, differentiation, growth and survival. Accordingly, the …

Abstract The cytokine interleukin-1 (IL-1) is important in many human diseases, and drives a
wide range of inflammatory responses in a number of cell types. Biological agents that target …