Metabolic alkalosis is a primary pathophysiologic event characterized by a gain of
bicarbonate or a loss of nonvolatile acid from extracellular fluid. More simply put, it is a …

Metabolic alkalosis is a primary pathophysiologic event characterized by the gain of
bicarbonate or the loss of nonvolatile acid from extracellular fluid. The kidney preserves …

Metabolic alkalosis is a primary rise in the concentration of bicarbonate in extracellular fluid
and can be divided into two phases: generation and maintenance. Generation requires …

Discussion DR. SANDRA SABATINI (Chairman and Professor of Physiology, and Professor
of Internal Medicine, Combined Program in Nephrology and Renal Physiology, Texas Tech …

The pathogenesis of metabolic alkalosis requires both the generation and the maintenance
of this disorder. Generation occurs as a result of net gain of bicarbonate ion (HCO3−) or net …

Metabolic alkalosis is caused by retention of excess alkali and is defined by a venous [total
CO2](a measured value) of greater than 30 mmol/l or an arterial [HCO3−](a calculated …

Metabolic alkalosis is common—half of all acid-base disorders at one medical center—and
severe cases are associated with substantial mortality. To understand the pathophysiology …

The pathogenesis of chronic metabolic alkalosis involves two distinct physiologic
derangements. First, there must be a loss of acid or gain of alkali in order to generate the …

The kidney is poised to defend against development of metabolic alkalosis through non-
adaptive mechanisms in the proximal nephron and adaptive processes in the distal …

In summary, the kidney possesses numerous mechanisms that help to prevent metabolic
alkalosis. Maintenance of metabolic alkalosis for any length of time means that renal …