A NUMBER of laboratories have reported the isolation from eukaryotic cells of mRNAs
linked covalently at their 3′-OH termini to polyadenylic add (poly (A)) 1–4. The chain of …

Poly (A) polymerase synthesizes poly (A) tails rapidly and processively only when the
substrate RNA is bound simultaneously by two stimulatory proteins, the cleavage and …

A SERIES of recent reports have demonstrated the covalent association of long polyadenylic
acid (poly A) sequences with mammalian cytoplasmic messenger RNA and with its putative …

A study of the processing of mRNA from two early adenovirus type 2 transcription units
(regions 2 and 4 of adenovirus type 2 genome;[J. Flint, Cell 10: 153--166, 1977]) revealed …

Gene expression can be controlled by changing the half-lifes of specific mRNAs in response
to intracellular events or to extracellular stimuli. Many experiments suggest that mRNA …

A HeLa cell 3'-exonuclease with properties of a mammalian mRNA poly (A) tail-removing
enzyme has been characterized. The exonuclease shows high specificity for the poly (A) tail …

Highly purified poly (A) polymerase (polynucleotide adenylyltransferase, EC 2.7. 7.19),
which synthesizes poly (A) from ATP substrate, can also catalyze hydrolysis of poly (A). The …

Three types of analysis of pulse-labeled nuclear RNA complementary to adenovirus region
2 (~ 50–75) from cells early in the infectious cycle showed that transcription regularly …

We constructed a retrovirus vector in which all viral transcriptional signals are deleted during
provirus formation. This vector would be safer and more useful in gene-transfer experiments …

Virtually all mRNAs in eucaryotes end in a poly (A) tail. This tail is added
posttranscriptionally. In this report, we demonstrate that the enzyme that catalyzes this …